H\u00fccre b\u00f6l\u00fcnmesi s\u0131ras\u0131nda kromozomlar\u0131n \u2018danslar\u0131’ ilk ortaya \u00e7\u0131kar\u0131ld\u0131\u011f\u0131 19. y\u00fczy\u0131l sonlar\u0131ndan beri biyologlar\u0131n ilgisini \u00e7ekmekte. B\u00f6l\u00fcnme s\u0131ras\u0131nda genetik bilginin h\u00fccrelere do\u011fru bi\u00e7imde da\u011f\u0131lmas\u0131nda anahtar rol oynayan \u201ckromozom-mekik\u201d ba\u011flant\u0131s\u0131n\u0131n molek\u00fc-ler \u00f6zellikleriyse uzun s\u00fcre gizemini korudu. Her bir h\u00fccre d\u00f6ng\u00fcs\u00fc s\u0131ras\u0131nda ya\u015fam\u0131n \u2018damgas\u0131’ konumundaki genomdan yeni bir kopya elde edilmesi ve bu genetik malzemenin de b\u00f6l\u00fcnmeyle ortaya \u00e7\u0131kan yavru h\u00fccrelere e\u015fit bi\u00e7imde da\u011f\u0131lmas\u0131 s\u00f6zkonusu. <\/p>\n
S\u00fcre\u00e7teki hatalarsa genetik kaynakl\u0131 bozukluklarla oldu\u011fu kadar kanserle de sonu\u00e7lanabiliyor. Bir canl\u0131n\u0131n genomunun, t\u00fcr\u00fcne ba\u011fl\u0131 olarak de\u011fi\u015fen say\u0131daki kromozomlara do\u011fru bi\u00e7imde da\u011f\u0131lmas\u0131ysa, \u201cmikrot\u00fcb\u00fcl\u201d ad\u0131 verilen \u00f6zel protein polimerlerine ba\u011fl\u0131. Genom kopyaland\u0131ktan sonra bu mikrot\u00fcb\u00fcl polimerleri, her iki ucu da tam olarak birer \u2018genom tak\u0131m\u0131’na ba\u011flanan mekik bi\u00e7imli bir yap\u0131 olu\u015fturuyorlar. Kromozomlar\u0131n bu mekik mikrot\u00fcb\u00fcl polimerlerine ba\u011flanmalar\u0131 engellendi\u011finde, h\u00fccre \u00e7o\u011falmas\u0131n\u0131n durdurulabilece\u011fi biliniyor (bu, bir\u00e7ok kanser t\u00fcr\u00fcn\u00fcn tedavisinde yararlan\u0131lan bir mekanizma).
\n Bilinmeyen, ba\u011flant\u0131n\u0131n kendisinin nas\u0131l kuruldu\u011fu.<\/p>\n
ABD\u2019deki California \u00dcniversitesi (San Diego) T\u0131p Okulu ve Ludwig Kanser Ara\u015ft\u0131rma Enstit\u00fcs\u00fc ara\u015ft\u0131rmac\u0131lar\u0131, b\u00f6l\u00fcnme s\u0131ras\u0131nda genomun iki kopyas\u0131n\u0131n birbirinden ayr\u0131lmas\u0131nda devreye giren kromozom-mekik ba\u011flant\u0131s\u0131n\u0131n yap\u0131s\u0131ndaki bir protein grubunu ortaya \u00e7\u0131kararak bu konuda \u00f6nemli bir ad\u0131m atm\u0131\u015f oldular. Bu protein grubunun en basit tek h\u00fccreli canl\u0131larda bile bulanmas\u0131ysa, bu g\u00f6revinin olduk\u00e7a eski ve korunmu\u015f oldu\u011funu g\u00f6steriyor. Bu, kanser h\u00fccrelerini hedefleyen yeni ila\u00e7lar\u0131n geli\u015ftirilmesi anlam\u0131na da geliyor. <\/p>\n
\u015eu anda kemoterapide kullan\u0131lan ila\u00e7lar\u0131n hemen hepsi b\u00fct\u00fcn v\u00fccut h\u00fccrelerindeki mikrot\u00fcb\u00fclleri etkilemekte. Bulgular do\u011frultusunda geli\u015ftirilecek yeni ila\u00e7lar\u0131nsa yaln\u0131zca b\u00f6l\u00fcnmekte olan kanser h\u00fccrelerini hedef alabilmesi olas\u0131l\u0131\u011f\u0131 y\u00fcksek.<\/p>\n
Ekibin bir ba\u015fka \u00e7al\u0131\u015fmas\u0131ysa, h\u00fccrenin kromozom-mekik ba\u011flant\u0131lar\u0131ndaki hatalar\u0131 ay\u0131rdederek b\u00f6l\u00fcnme s\u00fcrecini durdurmas\u0131na olanak tan\u0131yan ikinci bir protein kompleksini ortaya \u00e7\u0131karm\u0131\u015f bulunuyor. Bundan sonraki ad\u0131m, bu mekanizman\u0131n tam olarak nas\u0131l i\u015fledi\u011fini bulmak olacak.<\/p>\n","protected":false},"excerpt":{"rendered":"
H\u00fccre b\u00f6l\u00fcnmesi s\u0131ras\u0131nda kromozomlar\u0131n \u2018danslar\u0131’ ilk ortaya \u00e7\u0131kar\u0131ld\u0131\u011f\u0131 19. y\u00fczy\u0131l sonlar\u0131ndan beri biyologlar\u0131n ilgisini \u00e7ekmekte. B\u00f6l\u00fcnme s\u0131ras\u0131nda genetik bilginin h\u00fccrelere do\u011fru bi\u00e7imde da\u011f\u0131lmas\u0131nda anahtar rol oynayan \u201ckromozom-mekik\u201d ba\u011flant\u0131s\u0131n\u0131n molek\u00fc-ler \u00f6zellikleriyse uzun s\u00fcre gizemini korudu. Her bir h\u00fccre d\u00f6ng\u00fcs\u00fc s\u0131ras\u0131nda ya\u015fam\u0131n \u2018damgas\u0131’ konumundaki genomdan yeni bir kopya elde edilmesi ve bu genetik malzemenin de b\u00f6l\u00fcnmeyle ortaya …<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1407,1403],"tags":[2599,6220,6218,6219],"class_list":["post-2469","post","type-post","status-publish","format-standard","hentry","category-fen-ve-teknoloji-odevleri","category-odevler","tag-genetik","tag-kemoterapi","tag-kromozom-dansinin-perde-arkasi","tag-mikrotubul-polimerler"],"_links":{"self":[{"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/posts\/2469","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/comments?post=2469"}],"version-history":[{"count":0,"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/posts\/2469\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/media?parent=2469"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/categories?post=2469"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/tags?post=2469"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}