Protein molek\u00fcllerini] \u00e7o\u011fu biyolojik aktivitelerini ve etkinlik kape sitelerini \u00e7ok s\u0131n\u0131rl\u0131 ko\u015fullar i\u00e7erisinde koruya bilirler. Bu s\u0131n\u0131rlar\u0131n d\u0131\u015f\u0131na \u00e7\u0131k\u0131ld\u0131\u011f\u0131nda protei\u0131 molek\u00fcllerinde baz\u0131 de\u011fi\u015fmeler g\u00f6r\u00fcl\u00fcr ki i\u015fte b olaya denat\u00fcrasyon diyoruz. En g\u00f6ze \u00e7arpa; de\u011fi\u015fme glob\u00fcler proteinlerin s\u0131v\u0131lardaki \u00e7\u00f6zi; n\u00fcrl\u00fcklerinin azalarak \u00e7\u00f6kelmeye ba\u015flamalg r\u0131d\u0131r. Bu \u00f6zellik klinik analizlerde bir avantaj yg Tatmaktad\u0131r. \u0130nsan serumunda glukoz, \u00fcrikasit v gibi k\u00fc\u00e7\u00fck molek\u00fcll\u00fc unsurlar\u0131n analizlenebilmes i\u00e7in proteinlerin denat\u00fcrasyonla ortamdan uzat la\u015ft\u0131r\u0131lmalar\u0131 gereklidir. Proteinlerin \u00e7o\u011f\u0131 50\u00b0-60\u00b0C\u0092lik s\u0131cakl\u0131\u011f\u0131n \u00fczerine \u00e7\u0131k\u0131ld\u0131\u011f\u0131nd, denat\u00fcre olurlar. Ayn\u0131 olgu 10\u00b0-15\u00b0C s\u0131cakl\u0131\u011f\u0131: alt\u0131na inildi\u011fi zamanlarda da s\u00f6z konusu olmat tad\u0131r. Is\u0131ya ba\u011fl\u0131 protein denat\u00fcrasyonuna e: somut \u00f6rnek yumurtan\u0131n kaynat\u0131ld\u0131\u011f\u0131nda kat\u0131 bi yap\u0131ya d\u00f6n\u00fc\u015fmesidir. Yumurtan\u0131n \u00f6zellikleri de \u011fi\u015fmi\u015f, protein yap\u0131s\u0131 denat\u00fcre olmu\u015ftur. Denat\u00fcre olan proteinler ayn\u0131 zamanda biyoloji aktivitelerini de yitirirler. Enzimler \u0131s\u0131t\u0131ld\u0131klar\u0131! da reaksiyonlar\u0131 katalizleme yeteneklerini yitiri\u0131 ler. Proteinlerin \u00e7o\u011funda biyolojik aktiviteyi yo eden nedenlerin en \u00f6nemlileri, g\u00fc\u00e7l\u00fc mineral asi ve bazlar\u0131, \u0131s\u0131, iyonik deterjanlar, a\u011f\u0131r metalle [c\u0131va, kur\u015fun) ya da organik \u00e7\u00f6z\u00fcc\u00fclerdir.<\/p>\n","protected":false},"excerpt":{"rendered":"
Protein molek\u00fcllerini] \u00e7o\u011fu biyolojik aktivitelerini ve etkinlik kape sitelerini \u00e7ok s\u0131n\u0131rl\u0131 ko\u015fullar i\u00e7erisinde koruya bilirler. Bu s\u0131n\u0131rlar\u0131n d\u0131\u015f\u0131na \u00e7\u0131k\u0131ld\u0131\u011f\u0131nda protei\u0131 molek\u00fcllerinde baz\u0131 de\u011fi\u015fmeler g\u00f6r\u00fcl\u00fcr ki i\u015fte b olaya denat\u00fcrasyon diyoruz. En g\u00f6ze \u00e7arpa; de\u011fi\u015fme glob\u00fcler proteinlerin s\u0131v\u0131lardaki \u00e7\u00f6zi; n\u00fcrl\u00fcklerinin azalarak \u00e7\u00f6kelmeye ba\u015flamalg r\u0131d\u0131r. Bu \u00f6zellik klinik analizlerde bir avantaj yg Tatmaktad\u0131r. \u0130nsan serumunda glukoz, \u00fcrikasit …<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1407,1403],"tags":[7588,7822,2303,7823],"class_list":["post-3415","post","type-post","status-publish","format-standard","hentry","category-fen-ve-teknoloji-odevleri","category-odevler","tag-denaturasyon","tag-glukoz","tag-protein","tag-urikasit"],"_links":{"self":[{"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/posts\/3415","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/comments?post=3415"}],"version-history":[{"count":0,"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/posts\/3415\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/media?parent=3415"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/categories?post=3415"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.islamidavet.com\/kutuphane\/wp-json\/wp\/v2\/tags?post=3415"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}